UCLA Program on Genomics and Nutrition

Current Projects

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Genetic and Biochemical Predictors of Type 2 DM in Women
This project seeks to identify and confirm type 2 diabetes in the prospective Women’s Health Initiative (WHI) observational cohort. We examine specific gene-environment interactions (including the role of diet, exercise, and obesity itself) and risk of type 2 diabetes.
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WHI-SHARe

Steroid Hormones, Adipose-cytokines, and Diabetes Risk
This project proposes to establish type 2 diabetes as an endpoint in two ongoing clinical trials, the Women's Health Study (WHS) and the Physicians' Health Study (PHS) and investigate the roles of endogenous steroid hormones and adipokines and their physiological relevant genes in the development of type 2 diabetes in two prospective cohorts of men and women.

Magnesium Supplements, Plasma Inflammatory Markers, and Gene Expression
We conducted a randomized crossover pilot trial to examine the effects of oral Mg treatment on metabolic biomarkers and global genomic and proteomic profiling among overweight and obese individuals.

Shanghai Obesity and Diabetes Study (S.O.S.)
Type 2 diabetes (T2D) is fast becoming an epidemic in the People’s Republic of China, especially in urban regions where rapid socioeconomic and lifestyle changes have occurred. To identify risk factors that may provide etiologic insights specific to the Chinese population, we conducted a population-based case-control study in Shanghai, the largest Metropolitan city in China. From December 2006 to August 2007, we enrolled into the Shanghai Diabetes Study (SDS) 2,050 participants with T2D and 2,418 comparable controls of Han middle-aged or older adults. Lifestyles, dietary assessment, and biological samples were collected to investigate a comprehensive set of diabetes risk factors including demographic variables (age, sex, and education levels), lifestyle factors (cigarette smoking, alcohol consumption, physical activity, and family history of diabetes), anthropometric measures (body mass index, waist, and waist-hip ratio), and metabolic factors (blood pressure, fasting glucose, HbA1c, blood cholesterol and triglycerides) and relevant dietary variables. This study provides a comprehensive epidemiologic resource that will allows investigators to test numerous hypotheses related to genetic and environmental causes for T2D, ultimately allowing the development of specific preventive measures for this devastating disease in the Chinese Population.

GWAS of Treatment Response in Randomized Clinical Trials- Study Investigators
The goal of this project is to identify common variants that reproducibly alter risk of vascular events and diabetes after exposure to estrogen with or without progestin in postmenopausal women in the Women’s Health Initiative.

Telomere and its bio-regulators as predictors for clinical diabetes in women
This project seeks to examine the role of telomere length in peripheral monocytes in relation to the risk of type 2 diabetes in the prospective Women’s Health Initiative.

GARNET (Genomics and Randomized Trials Network, or Genome-wide Association Research Network into Effects of Treatment)
GARNET, a series of genome-wide association studies of treatment response in randomized clinical trials, utilizes existing clinical trial data and sample resources to identify genetic variants that influence an individual’s response to treatment and determine whether specific treatments are more or less effective in groups defined by genotype. Also, this project aims to develop and disseminate innovative methods for adding genome-wide technologies to randomized clinical trials and interpreting the results in the context of a randomized treatment assignment.

Previous Projects and Data Resources

Breast and Prostate Cancer and Hormone-Related Gene Variants Cohort Consortium

Behavioral Risk Factor Surveillance System (BRFSS)

National Health And Nutrition Examination Survey (NHANES)

Please visit our Resources section for project ideas, data references and tools.