UCLA Program on Genomics and Nutrition

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Epi 233C Research Synthesis and Meta-Analysis Applications in Public Health and Clinical Medicine: Critical and quantitative assessment of biomedical literatures and technologies
Syllabus and Readings

Concerned with the explosion of biological data for etiologic inquiry and the use of existing data to inform clinical decision making and health care policy, the course focuses on research synthesis and evidence-based medicine and public health including screening and high-risk assessment. The epidemiologic principles and relevant statistical methods are reviewed and applied to real case studies. Application of methods includes considerations for randomized clinical trials and observational studies of various topics. The use of meta-analysis to explore data and identify sources of variation among studies is emphasized, as is the use of meta-analysis to identify future research questions. This course introduces students to the science of research synthesis (both qualitative and quantitative). Principles and methods in conducting a systematic and quantitative review are illustrated through case studies of medical and public health issues, with emphasis on exploring inconsistent or controversial issues and identifying their sources of variations. The philosophical bases for individual vs. population approaches inherent in many biomedical settings also will be exposed and critically evaluated.

Epi 258 Molecular Nutrition and Genetic Epidemiology of Obesity and Diabetes
Syllabus and Readings

This course surveys the entire landscape of the nutritional, biochemical, and genetic aspects of obesity (overweight, obesity, and extreme obesity), diabetes (type 1 and type 2), and their micro- and macro-vascular complications. The descriptive and analytical epidemiology of these seemingly distinct yet clearly clustered disorders including the so-called metabolic syndrome will be reviewed comprehensively and in-depth. It is hoped that through studying the distributions and determinants of these highly prevalent disorders in urbanized populations, students will appreciate how and why these “epidemics of our time” occurred. Through case studies, the students will learn the process of generating etiologic hypotheses that can be tested using a myriad of modern molecular epidemiologic methods. Techniques and principal of molecular nutrition and genetics relevant to epidemiologic studies will be reviewed and demonstrated. Real data sets which include both genotype and phenotype information will be analyzed with emphasis placed on the examination of various gene/environment interactions. International comparison of prevalent data in different social contexts will also be reviewed, so that the strategies for prevention by either changing our cultures or natures can be appreciated and debated with a better understanding of the related issues confronted by public health and medical professionals.
Epi 297 Advanced Seminar in Nutrition and Genomics
Syllabus and Readings

The aim of this course is to present current topics that are not covered in other molecular epidemiology courses offered in the Department of Epidemiology including Epi 258. This new series of seminars attempts to explore recent developments (including those ongoing in the Program on Genomics and Nutrition http://nutrigen.ph.ucla.edu ) in molecular and nutritional aspects of metabolic diseases (broadly defined), including molecular markers of dietary and environmental exposures along with their applications to disease risk assessment in the context of individual genetic markers of susceptibility. While the focus will change from year to year, students will be required to present their own projects or key papers in the literature to assess background and significance of a substantive topic for discussion. Applications will mainly cover phenotypic endpoints related to cancer, cardiovascular disease, diabetes and obesity. The teaching of successful meta-analytical, research paper, grant writings will also be included when appropriate.

Epi 254 Nutritional Epidemiology
Syllabus and Readings

Reviews all aspects of contemporary nutrition sciences that require the application of epidemiologic principles and methods ranging from food-born outbreak investigation to evidence-based regulatory assessment of health claims for foods. It is intended for students to gain experience in the actual world of collecting, analyzing and interpreting data related to nutrition and health or disease outcomes.

Epi 257 Advanced Nutritional Epidemiology
Syllabus and Readings

This course moves beyond topics in Epi 254 and addresses methodological aspects of research in nutritional epidemiology. Topics include why and how to conduct validation studies, adjustment for confounding, considerations of total energy intake and intermediary phenotypes, correction of measurement error, concepts of interaction and interpretation, various methods in making conditional inference in observational settings. Theoretical as well as practical aspects will be covered. This course is intended primarily for doctoral students interested in doing epidemiologic research.

Affiliated Classes

To view more classes affiliated with the PGN program, please visit the BWF-IT-MD Training Program website.